NAD+ & longevity

What’s being published about NAD+.

Research and coverage from the field — the useful, the early, and the overstated. Every item links to its source. None of it is about AgeleX.

Research

Scientific Reports

2019

Two weeks of oral NR raised whole-blood NAD+ by 51% at 300 mg and 142% at 1,000 mg

Randomised, double-blind, placebo-controlled · n=140 · healthy overweight adults 40–60 · Conze D, Brenner C, Kruger CL

The dose-response trial the 500 mg serving in AgeleX sits inside. It measured NAD+ in blood, not health outcomes.

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Worth a caveat

Nature Communications

2018

NR is safe in healthy middle-aged adults — and did not move blood pressure at the group level

Randomised, double-blind, placebo-controlled crossover · Martens CR, et al.

Worth reading precisely because the headline finding is a null one. This is where the category's promises tend to get ahead of the data.

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Research

Cell Reports

2019

NR raises NAD+ in aged human skeletal muscle

Older men · muscle biopsies · Elhassan YS, et al.

Tissue-level rather than blood-level — a harder measurement, and a narrower population.

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Research

PLoS ONE

2012

NAD+ declines with age in human tissue

Human tissue samples · Massudi H, et al.

The measurement the whole category is built on — and the one most often quoted without its bounds.

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Everything on this page is about NAD+ and its precursors as a field. None of these researchers or publications has any relationship with AgeleX, and nothing here is an endorsement of any product.‡

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
† Individual results may vary.
‡ Cited results describe studied ingredients, not the finished AgeleX product.